Hydracrylonitrile → Bis(2-cyanoethyl) phosphorochloridite

Reaktionsgleichung

[OH:1][CH2:2][CH2:3][C:4]#[N:5].C([N:8]([CH2:11][CH3:12])CC)C.[P:13]([Cl:16])(Cl)Cl.C1C[O:20][CH2:19]C1>>[P:13]([Cl:16])([O:20][CH2:19][CH2:12][C:11]#[N:8])[O:1][CH2:2][CH2:3][C:4]#[N:5]

Komponenten

Edukt 4

HCID 8011Hydracrylonitrile

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 24387Phosphorus trichloride

Produkt 1

HCID 11390133Bis(2-cyanoethyl) phosphorochloridite

Versuchsvorschrift

In the second reaction vessel 3-hydroxypropionitrile (20 mmol) and triethylamine (2.8 mL, 20 mmol) were added to a solution of phosphorus trichloride (10 mmol) in THF (25 mL) under dry nitrogen. The mixture was stirred for 10 min at room temperature to give bis(2-cyanoethyl) phosphorochloridite (28).