3-(4-Cyano-3-fluorophenyl)-1-propene → 2-Fluoro-4-[2-(piperazin-1yl)ethyl]benzonitrile
Reaktionsgleichung
[F:1][C:2]1[CH:9]=[C:8]([CH2:10][CH:11]=C)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].COC1C=C(CC[N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)C=CC=1C#N>>[F:1][C:2]1[CH:9]=[C:8]([CH2:10][CH2:11][N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]Komponenten
3
Versuchsvorschrift
2-Fluoro-4-[2-(piperazin-1yl)ethyl]benzonitrile was prepared from 2-fluoro-4-(prop-2-en-1-yl)benzonitrile (described above) in an analogous fashion to that described for 2-methoxy-4-[2-(piperazin-1-yl)ethyl]benzonitrile.
Quellen und Nachweise
- ORD-Eintrag
- ord-ecfe64f8682642aaa6bf4d175e6fa79f
- Quelldatensatz
- uspto-grants-2015_06
- Patentnummer
- US09056859B2
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