3-Bromo-6-fluoro-2-methylbenzonitrile → 6-Fluoro-2-methyl-3-(2-oxoethyl)benzonitrile
Reaktionsgleichung
Br[C:2]1[C:3]([CH3:11])=[C:4]([C:7]([F:10])=[CH:8][CH:9]=1)[C:5]#[N:6].ClC1C([CH2:21][CH:22]=[O:23])=CC=C(F)C=1C#N>>[F:10][C:7]1[C:4]([C:5]#[N:6])=[C:3]([CH3:11])[C:2]([CH2:21][CH:22]=[O:23])=[CH:9][CH:8]=1Komponenten
3
Versuchsvorschrift
6-Fluoro-2-methyl-3-(2-oxoethyl)benzonitrile was prepared in two steps starting from 3-bromo-6-fluoro-2-methylbenzonitrile in an analogous fashion to that described for the synthesis of 2-chloro-6-fluoro-3-(2-oxoethyl)benzonitrile (Steps B and C) above.
Quellen und Nachweise
- ORD-Eintrag
- ord-aa9c41276b6e4326ad3a7f3bc4bf9c08
- Quelldatensatz
- uspto-grants-2015_06
- Patentnummer
- US09056859B2
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