Triethylamine → (+/-)-1-Acetyl-4-acetylthio-2-pyrrolidone

HRID 21737

Reaktionsgleichung

Reaktionsgleichung von HRID 21737
[C:1]([N:4]1[CH2:8][C@H:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2].C(N(CC)CC)C.S1C=CC=C1CC(O)=O>C(OCC)(=O)C>[C:1]([N:4]1[CH2:8][CH:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 159702-Thiopheneacetic acidHCID 86748734(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone

Produkt 1

HCID 86748735(+/-)-1-Acetyl-4-acetylthio-2-pyrrolidoneAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone (3 g) and triethylamine (2.1 ml) are dissolved in ethyl acetate (30 ml), and the mixture is refluxed for three hours, and then allowed to stand at room temperature for 8 hours. To the reaction solution is added thiolacetic acid (1.2 ml), and the mixture is stirred at room temperature for 5 hours. The reaction solution is washed with water, dried, and evaporated to remove the solvent to give (±)-1-acetyl-4-acetylthio-2-pyrrolidone (2.7 g).

Aufarbeitung

  1. temperaturethe mixture is refluxed for three hours
  2. washThe reaction solution is washed with water
  3. customdried
  4. customevaporated
  5. customto remove the solvent

Quellen und Nachweise

ORD-Eintrag
ord-78b65f57d4cc4543959bfb9496b3572a
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05424446

Verknüpfte Notizen

Wird geladen…