Ethanol → HCID 86712399, Verbindung

Reaktionsgleichung

S(=O)(=O)(O)O.[F:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[N:15]=[CH:14][C:13]([O:17][C:18]1[C:19]([C:24]([CH3:28])([CH3:27])[C:25]#N)=[N:20][CH:21]=[CH:22][CH:23]=1)=[CH:12]2.C(=O)([O-])[OH:30].[Na+].[CH2:34]([OH:36])[CH3:35]>>[CH2:34]([O:36][C:25](=[O:30])[C:24]([C:19]1[C:18]([O:17][C:13]2[CH:14]=[N:15][C:16]3[C:11]([CH:12]=2)=[CH:10][CH:9]=[CH:8][C:7]=3[F:6])=[CH:23][CH:22]=[CH:21][N:20]=1)([CH3:27])[CH3:28])[CH3:35]

Komponenten

Edukt 4

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 516892Sodium Bicarbonate

HCID 86712397HCID 86712397, Verbindung

Produkt 1

HCID 86712399HCID 86712399, Verbindung

Reaktionsbedingungen

Temperatur: 100 °C

Versuchsvorschrift

2 ml of ethanol and 2 ml of concentrated sulfuric acid were added to 0.38 g of 2-[3-(8-fluoro-quinolin-3-yloxy)-pyridin-2-yl]-2-methylpropionitrile. The mixture was stirred for 6 hours at 100° C. Subsequently, saturated aqueous sodium hydrogen carbonate solution was added thereto to stop the reaction. The resultant was then extracted with ethyl acetate followed by distilling off the solvent of the organic layer. Subsequently, the resultant was purified by silica gel column chromatography to obtain 0.24 g of 2-[3-(8-fluoro-quinolin-3-yloxy)-pyridin-2-yl]-2-methylpropionic acid ethyl ester.