Reaktionsgleichung
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.S(=O)(=O)(O)O.[CH3:20]O>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:20])=[O:7])=[C:4]([C:11]([F:12])([F:13])[F:14])[CH:3]=1Komponenten
4
Versuchsvorschrift
To a solution of 4-fluoro-2-(trifluoromethyl)benzoic acid in MeOH were added concentrated sulfuric acid at 0° C. The reaction mixture was heated and refluxed for 2 days. The reaction mixture was concentrated under reduced pressure and the residue was diluted with EtOAc. The organic layer was washed with a saturated aqueous NaHCO3 solution, dried over MgSO4, and then concentrated under reduced pressure to obtain methyl 4-fluoro-2-(trifluoromethyl)benzoate as a colorless oily substance.
Aufarbeitung
- temperatureThe reaction mixture was heated
- temperaturerefluxed for 2 days
- concentrationThe reaction mixture was concentrated under reduced pressure
- additionthe residue was diluted with EtOAc
- washThe organic layer was washed with a saturated aqueous NaHCO3 solution
- dry with materialdried over MgSO4
- concentrationconcentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-9d95e702b944488eba81ae0c24af7c6f
- Quelldatensatz
- uspto-grants-2012_06
- Patentnummer
- US08193378B2
Verknüpfte Notizen
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