2-Iodo-3-methylbenzoic acid → Methyl 2-iodo-3-methylbenzoate

Reaktionsgleichung

[I:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:12](Cl)Cl.CO>>[I:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:12])=[O:5]

Komponenten

Edukt 2

HCID 27593652-Iodo-3-methylbenzoic acid

HCID 21226129Dichloromethane methanol

Produkt 1

HCID 13924925Methyl 2-iodo-3-methylbenzoate

Versuchsvorschrift

2-iodo-3-methylbenzoic acid (595 mg, 2.27 mmol) was dissolved in DCM/MeOH=1/1 (5 ml) at 0° C., then TMS-CH2N2 (2M in Et2O, 1.4 ml, 2.8 mmol) was added. After 1.5 hours at RT solvents were evaporated. Yield 630 mg yellow oil.

Aufarbeitung

customAfter 1.5 hours at RT solvents were evaporated

Quellen und Nachweise

ORD-Eintrag: ord-8262197c8ae54385a67703552e0e64e3
Quelldatensatz: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09062033B2

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