Trifluoroacetic acid → HCID 67086667, Verbindung

HRID 2174972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2174972
C(OC([N:8]1[CH2:15][CH2:14][CH:13]2[CH:10]([N:11]([C:16]([C:18]3[C:19]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:20][CH:21]=[CH:22][CH:23]=3)=[O:17])[CH2:12]2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>O1CCOCC1>[C:19]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:16]([N:11]1[CH:10]2[CH:13]([CH2:14][CH2:15][NH:8][CH2:9]2)[CH2:12]1)=[O:17]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67086573HCID 67086573, Verbindung

Produkt 1

HCID 67086667HCID 67086667, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of 8-(biphenyl-2-carbonyl)-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester in dioxane (8.0 mL) was added trifluoro acetic acid (3 mL), the reaction mixture was stirred for 16 h at room temperature. The solvent and the excess of trifluoro acetic acid were removed under reduced pressure. The resulting trifluoro acetic acid salt of the title compound (388.0 mg was used crude without further purification. MS (ESI) mass calcd. for C19H20N2O, 292.37; m/z found, 293.2 [M+H]+.

Aufarbeitung

  1. customThe solvent and the excess of trifluoro acetic acid were removed under reduced pressure
  2. customwithout further purification

Quellen und Nachweise

ORD-Eintrag
ord-3d9f1bf10e9b4ec69639be730a949fe8
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09062044B2

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