Trifluoroacetic acid → 8-(2,4-Dimethyl-benzenesulfonyl)-3,8-diaza-bicyclo[4.2.0]octane

HRID 2174974Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2174974
C(OC([N:8]1[CH2:15][CH2:14][CH:13]2[CH:10]([N:11]([S:16]([C:19]3[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:20]=3[CH3:26])(=[O:18])=[O:17])[CH2:12]2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>O1CCOCC1>[CH3:26][C:20]1[CH:21]=[C:22]([CH3:25])[CH:23]=[CH:24][C:19]=1[S:16]([N:11]1[CH:10]2[CH:13]([CH2:14][CH2:15][NH:8][CH2:9]2)[CH2:12]1)(=[O:18])=[O:17]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 670865848-(2,4-Dimethyl-benzenesulfonyl)-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester

Produkt 1

HCID 670869158-(2,4-Dimethyl-benzenesulfonyl)-3,8-diaza-bicyclo[4.2.0]octane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of 8-(2,4-dimethyl-benzenesulfonyl)-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester in dioxane (8 mL) was added trifluoro acetic acid (3 mL), the reaction mixture was stirred for 16 h at room temperature. The solvent and the excess of trifluoro acetic acid were removed under reduced pressure. The resulting trifluoro acetic acid salt of the title compound was used crude without further purification (150.0 mg, 49%). MS (ESI) mass calcd. for C14H20N2O4S, 280.39; m/z found, 281.2 [M+H]+.

Aufarbeitung

  1. customThe solvent and the excess of trifluoro acetic acid were removed under reduced pressure
  2. customwithout further purification (150.0 mg, 49%)

Quellen und Nachweise

ORD-Eintrag
ord-135325c18fa741f38a73749bec2aad92
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09062044B2

Notizen zur Reaktion

Wird geladen…