Hydrochloric Acid → (1R,2S,3R)-3-[6'-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,4,5,6-tetrahydro-2H-1,2'-bi pyridinyl-4-ylamino]cyclohexane-1,2-diol

HRID 2175105Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2175105
Cl.CC1(C)[O:7][C@@H:6]2[CH2:8][CH2:9][CH2:10][C@@H:11]([NH:12][CH:13]3[CH2:18][CH2:17][N:16]([C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([C:25]5[CH:34]=[CH:33][C:32]6[C:31]([CH3:36])([CH3:35])[CH2:30][CH2:29][C:28]([CH3:38])([CH3:37])[C:27]=6[CH:26]=5)[N:20]=4)[CH2:15][CH2:14]3)[C@@H:5]2[O:4]1>CO>[CH3:35][C:31]1([CH3:36])[CH2:30][CH2:29][C:28]([CH3:37])([CH3:38])[C:27]2[CH:26]=[C:25]([C:21]3[N:20]=[C:19]([N:16]4[CH2:15][CH2:14][CH:13]([NH:12][C@@H:11]5[CH2:10][CH2:9][CH2:8][C@@H:6]([OH:7])[C@H:5]5[OH:4])[CH2:18][CH2:17]4)[CH:24]=[CH:23][CH:22]=3)[CH:34]=[CH:33][C:32]1=2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67249330((3aS,4R,7aR)-2,2-Dimethylhexahydrobenzo-1,3-dioxol-4-yl)-[6'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,4,5,6-tetrahydro-2H-1,2'-bipyridinyl-4-yl]amine

Produkt 1

HCID 68380130(1R,2S,3R)-3-[6'-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,4,5,6-tetrahydro-2H-1,2'-bi pyridinyl-4-ylamino]cyclohexane-1,2-diol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

10 ml of 1.25 N HCl in methanol are added to 91 mg of ((3aS,4R,7aR)-2,2-dimethylhexahydrobenzo-1,3-dioxol-4-yl)-[6′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,4,5,6-tetrahydro-2H-1,2′-bipyridinyl-4-yl]amine, and the mixture is stirred at room temperature overnight. The reaction mixture is evaporated and dried under high vacuum. The product is in the form of the hydrochloride.

Aufarbeitung

  1. customThe reaction mixture is evaporated
  2. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-6d26b7833ec143acac659511794833b9
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09062015B2

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