2,2,2-Cryptand → 4-(Fluoromethyl)benzaldehyde

HRID 217556

Reaktionsgleichung

Reaktionsgleichung von HRID 217556
[F-:1].[K+].C1N2CCOCCOCCN(CCOCCOCC2)CCOCCOC1.CS([O:33][CH2:34][C:35]1[CH:40]=[CH:39][C:38]([CH:41]=O)=[CH:37][CH:36]=1)(=O)=O>C(#N)C>[F:1][CH2:41][C:38]1[CH:39]=[CH:40][C:35]([CH:34]=[O:33])=[CH:36][CH:37]=1

Komponenten

5

Edukt 3

HCID 728012,2,2-CryptandHCID 522689Potassium FluorideHCID 12134352HCID 12134352, Verbindung

Produkt 1

HCID 214079014-(Fluoromethyl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

KF (2.7 mg, 0.047 mmol) and kryptofix 222 (17.6 mg, 0.047 mmol) were dissolved in acetonitrile (1 ml) and added to (4-formylphenyl)methyl methanesulfonate (10 mg, 0.047 mmol) in acetonitrile (1 ml). The reaction mixture was heated to 65 degrees for 10 minutes. The crude product was purified using a silica short column and diethyl ether. (Analytical HPLC: column Phenomenex Luna 00B-4251-E0, solvents: A=water/0.1% TFA and B=CH3CN/0.1% TFA; gradient 5-50% B over 10 min; flow 2.0 ml/minute; retention time 5.1 minutes detected at 214 and 254 nm).

Aufarbeitung

  1. temperatureThe reaction mixture was heated to 65 degrees for 10 minutes
  2. customThe crude product was purified

Quellen und Nachweise

ORD-Eintrag
ord-1030369a0e3c4e0385f32c9e98a65080
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08197793B2

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