Cyanomethylenetributylphosphorane → (9aR)-tert-butyl 3-(2-chloro-3-cyano-4-fluorophenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate

HRID 2175868Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2175868
[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([F:10])[CH:5]=[CH:4][C:3]=1[CH:11](O)[CH2:12][N:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][C@@H:14]1[CH2:26][OH:27].C(C=P(CCCC)(CCCC)CCCC)#N>C1C=CC=CC=1>[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([F:10])[CH:5]=[CH:4][C:3]=1[CH:11]1[O:27][CH2:26][C@H:14]2[CH2:15][N:16]([C:19]([O:21][C:22]([CH3:24])([CH3:25])[CH3:23])=[O:20])[CH2:17][CH2:18][N:13]2[CH2:12]1

Komponenten

4

Edukt 2

HCID 4622928CyanomethylenetributylphosphoraneHCID 86727083HCID 86727083, Verbindung

Produkt 1

HCID 71273621(9aR)-tert-butyl 3-(2-chloro-3-cyano-4-fluorophenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

(3R)-tert-butyl 4-(2-(2-chloro-3-cyano-4-fluorophenyl)-2-hydroxyethyl)-3-(hydroxymethyl)piperazine-1-carboxylate (15.6 g, 37.3 mmol) and cyanomethylene tri-n-butyl phosphorane (16.4 g, 67.8 mmol) were dissolved in benzene (90 mL), degassed and heated at 100° C. for 16 h. The reaction mixture was concentrated and chromatographed through a 330 g ISCO Redi-sep column and eluted with 35% EtOAc/hexane to yield the title compound (cis-trans diastereomers mixture). LC-MS (IE, m/z): 396 [M+1]+;

Aufarbeitung

  1. customdegassed
  2. concentrationThe reaction mixture was concentrated
  3. customchromatographed through a 330 g ISCO Redi-sep column
  4. washeluted with 35% EtOAc/hexane

Quellen und Nachweise

ORD-Eintrag
ord-7cfb606cd06a4a36b9bf43b64b60bf9a
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09062070B2

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