2,6-Difluoro-3-nitrobenzoyl chloride → (3-Amino-2,6-difluoro-phenyl)-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone
Reaktionsgleichung
[F:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[C:7]([F:14])[C:3]=1[C:4](Cl)=[O:5].[CH3:15][C:16]1[CH:17]=[C:18]2[CH:24]=[CH:23][NH:22][C:19]2=[N:20][CH:21]=1>>[NH2:11][C:10]1[C:2]([F:1])=[C:3]([C:4]([C:24]2[C:18]3[C:19](=[N:20][CH:21]=[C:16]([CH3:15])[CH:17]=3)[NH:22][CH:23]=2)=[O:5])[C:7]([F:14])=[CH:8][CH:9]=1Komponenten
3
Versuchsvorschrift
(3-Amino-2,6-difluoro-phenyl)-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone 17 was prepared in two steps from 2,6-difluoro-3-nitro-benzoyl chloride 14 and 5-methyl-1H-pyrrolo[2,3-b]pyridine 15 as shown in Scheme 1a.
Quellen und Nachweise
- ORD-Eintrag
- ord-1e7d9015c8dc432380832ceab9661323
- Quelldatensatz
- uspto-grants-2012_06