Hydrochloric Acid → 2-amino-6,7-dihydro-5H-cyclopenta[d]pyrimidine-5-carboxylic acid

HRID 2175927Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2175927
[OH-].[Na+].[NH2:3][C:4]1[N:5]=[CH:6][C:7]2[CH:12]([C:13]([O:15]C)=[O:14])[CH2:11][CH2:10][C:8]=2[N:9]=1.Cl>CO>[NH2:3][C:4]1[N:5]=[CH:6][C:7]2[CH:12]([C:13]([OH:15])=[O:14])[CH2:11][CH2:10][C:8]=2[N:9]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86727113methyl 2-amino-6,7-dihydro-5H-cyclopenta[d]pyrimidine-5-carboxylate

Produkt 1

HCID 838618122-amino-6,7-dihydro-5H-cyclopenta[d]pyrimidine-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Sodium hydroxide (13.0 mL, 13.0 mmol) was added to a solution of methyl 2-amino-6,7-dihydro-5H-cyclopenta[d]pyrimidine-5-carboxylate (1.10 g, 5.69 mmol) in methanol (21 mL). The resulting mixture was stirred at RT for 1.5 hours. Hydrochloric acid (13 mL, 13.00 mmol) was added. The solvent was evaporated. The residue was purified by chromatography on silica (24 g cartridge) eluting with CH2Cl2:MeOH 95:5 (150 mL) and CH2Cl2:MeOH:AcOH 90:10:1 to afford the title compound.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customThe residue was purified by chromatography on silica (24 g cartridge)
  3. washeluting with CH2Cl2:MeOH 95:5 (150 mL) and CH2Cl2:MeOH:AcOH 90:10:1

Quellen und Nachweise

ORD-Eintrag
ord-1b8bf926f96d474dab99129277f98c06
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09062070B2

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