3,4-Difluorophenyl isocyanate → N-(4-t-Butoxycarbonylaminothiophen-3-yl)-5-[3-(3,4-difluorophenyl)-1-[3-(morpholin-4-yl)propyl]ureidomethyl]pyridine-2-carboxylic acid amide

HRID 217636

Reaktionsgleichung

Reaktionsgleichung von HRID 217636
[F:1][C:2]1[CH:3]=[C:4]([N:9]=[C:10]=[O:11])[CH:5]=[CH:6][C:7]=1[F:8].[C:12]([O:16][C:17]([NH:19][C:20]1[C:21]([NH:25][C:26]([C:28]2[CH:33]=[CH:32][C:31]([CH2:34][NH:35][CH2:36][CH2:37][CH2:38][N:39]3[CH2:44][CH2:43][O:42][CH2:41][CH2:40]3)=[CH:30][N:29]=2)=[O:27])=[CH:22][S:23][CH:24]=1)=[O:18])([CH3:15])([CH3:14])[CH3:13]>ClCCl>[C:12]([O:16][C:17]([NH:19][C:20]1[C:21]([NH:25][C:26]([C:28]2[CH:33]=[CH:32][C:31]([CH2:34][N:35]([CH2:36][CH2:37][CH2:38][N:39]3[CH2:40][CH2:41][O:42][CH2:43][CH2:44]3)[C:10]([NH:9][C:4]3[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=3)=[O:11])=[CH:30][N:29]=2)=[O:27])=[CH:22][S:23][CH:24]=1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

Komponenten

4

Edukt 2

HCID 27347083,4-Difluorophenyl isocyanateHCID 67049993N-(4-t-butoxycarbonylaminothiophen-3-yl)-5-[3-(morpholin-4-yl)propylaminomethyl]pyridine-2-carboxylic acid amide

Produkt 1

HCID 67050108N-(4-t-Butoxycarbonylaminothiophen-3-yl)-5-[3-(3,4-difluorophenyl)-1-[3-(morpholin-4-yl)propyl]ureidomethyl]pyridine-2-carboxylic acid amideAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3,4-Difluorophenyl isocyanate (15 μL, 0.13 mmol) was added to a solution of N-(4-t-butoxycarbonylaminothiophen-3-yl)-5-[3-(morpholin-4-yl)propylaminomethyl]pyridine-2-carboxylic acid amide (Reference Compound No. 5-12, 43 mg, 0.091 mmol) in dichloromethane (2.0 mL), and then the reaction mixture was stirred at room temperature for 1.5 hours. The reaction solution was purified by silica gel column chromatography (chloroform-methanol) to give 53 mg of the title reference compound as a colorless solid. (Yield 92%)

Aufarbeitung

  1. customThe reaction solution was purified by silica gel column chromatography (chloroform-methanol)
  2. customto give 53 mg of the title reference compound as a colorless solid

Quellen und Nachweise

ORD-Eintrag
ord-c729d5e047b94b388dc7389eadae3c71
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198271B2

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