Ammonia → 2-(4-Methoxyphenyl)acetamide

HRID 2176876Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2176876
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.S(Cl)(Cl)=O.[NH3:17]>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([NH2:17])=[O:12])=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 76904-Methoxyphenylacetic AcidHCID 24386Thionyl Chloride

Produkt 1

HCID 2418682-(4-Methoxyphenyl)acetamideAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 2-(4-methoxyphenyl)acetic acid (500 mg, 3.00 mmol) in DCM (30 ml) was added thionyl chloride (0.4 ml, 4.5 mmol) at 0° C. The reaction mixture was allowed to warm up to room temperature and continued to stirred overnight. Then aqueous ammonia (2 ml) was added to the reaction mixture. The white solid forming was filtered and dried under vacuum to obtained 350 mg (70%) of 2-(4-methoxyphenyl)acetamide as a white solid.

Aufarbeitung

  1. customThe white solid forming
  2. filtrationwas filtered
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-41bb5eaa0b9e40788f67484ffa0c3eae
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09067888B2

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