L-Proline → 1-L-Alanyl-D-proline
Reaktionsgleichung
N1CCC[C@H]1C(O)=O.[NH2:9][C@@H:10]([C:12]([N:14]1[CH2:21][CH2:20][CH2:19][C@@H:15]1[C:16]([OH:18])=[O:17])=[O:13])[CH3:11]>>[NH2:9][C@H:10]([C:12]([N:14]1[CH2:21][CH2:20][CH2:19][C@@H:15]1[C:16]([OH:18])=[O:17])=[O:13])[CH3:11]Komponenten
3
Versuchsvorschrift
By substituting D-proline for L-proline in the above example, a 70% diastereomeric excess mixture of D-alanyl-D-proline and L-alanyl-D-proline was obtained.
Quellen und Nachweise
- ORD-Eintrag
- ord-7c5c474dbd28494d887887522b80854c
- Quelldatensatz
- uspto-grants-1995_06
- Patentnummer
- US05424454
Notizen zur Reaktion
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