HCID 178494163, Verbindung → HCID 178494166, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:10]=[C:11]([NH:14][C:15]3[CH:20]=[N:19][CH:18]=[C:17]([O:21][C@@H:22]4[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]4)[N:16]=3)[NH:12][N:13]=2)=[CH:7][CH:6]=[C:5]([CH3:28])[N:4]=1>O.C(O)C>[OH2:2].[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:10]=[C:11]([NH:14][C:15]3[CH:20]=[N:19][CH:18]=[C:17]([O:21][C@@H:22]4[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]4)[N:16]=3)[NH:12][N:13]=2)=[CH:7][CH:6]=[C:5]([CH3:28])[N:4]=1Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Suspend (R)-[5-(2-methoxy-6-methyl-pyridin-3-yl)-2H-pyrazol-3-yl]-[6-(piperidin-3-yloxy)-pyrazin-2-yl]-amine (52.1 mg; ES/MS m/z 382.2 [M+H]+) in 5.95 water-ethanol mixture (10 mL) and slurry at ambient temperature for 48 hours. A white crystalline solid is recovered by vacuum filtration.
Aufarbeitung
- filtrationA white crystalline solid is recovered by vacuum filtration