5-Cyano-3-methylpyridine-2-carboxylic acid → N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide
Reaktionsgleichung
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:20])=[C:6]([C@:8]2([CH3:19])[CH2:13][C@@H:12]([C:14]([F:17])([F:16])[F:15])[O:11][C:10]([NH2:18])=[N:9]2)[CH:7]=1.[C:21]([C:23]1[CH:24]=[C:25]([CH3:32])[C:26]([C:29](O)=[O:30])=[N:27][CH:28]=1)#[N:22]>>[NH2:18][C:10]1[O:11][C@H:12]([C:14]([F:16])([F:17])[F:15])[CH2:13][C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:29](=[O:30])[C:26]3[C:25]([CH3:32])=[CH:24][C:23]([C:21]#[N:22])=[CH:28][N:27]=3)[CH:3]=[CH:4][C:5]=2[F:20])([CH3:19])[N:9]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The coupling of (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (XI-1) and 5-cyano-3-methylpicolinic acid [S. Badiger et al. WO2011009943 (2011)] following General Procedure G yielded the title compound as a colorless amorphous solid. MS: m/z=436.5 [M+H]+.