Sodium Carbonate → HCID 67313922, Verbindung

Temperatur

80 °C

100 mg (0.25 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-bromo-1-benzothiophene-2-carboxamide hydrochloride (Example 11A) and 51.5 mg (0.25 mmol) of 4-morpholinophenylboronic acid are introduced into 1 ml of DMF. Addition of 0.37 ml of 2 M sodium carbonate solution and 10.2 mg (0.01 mmol) of PdCl2(dppf) is followed by heating to 80° C. After 16 h, a further 51.5 mg (0.25 mmol) of 4-morpholinophenylboronic acid, 0.37 ml of 2 M sodium carbonate solution and 10.2 mg (0.01 mmol) of PdCl2(dppf) are added. The mixture is heated at 80° C. for a further 4 h. After cooling, the reaction mixture is filtered through kieselguhr and purified by preparative HPLC. The product fractions are concentrated and, after addition of a 5:1 mixture of methanol and 4 M hydrogen chloride in dioxane, again concentrated. Drying under high vacuum results in 83 mg (69% of theory) of the title compound.

1. temperatureThe mixture is heated at 80° C. for a further 4 h
2. temperatureAfter cooling
3. filtrationthe reaction mixture is filtered through kieselguhr
4. custompurified by preparative HPLC
5. concentrationThe product fractions are concentrated
6. additionafter addition of a 5:1 mixture of methanol and 4 M hydrogen chloride in dioxane
7. concentrationagain concentrated
8. customDrying under high vacuum

ORD-Eintrag

ord-157d80e747344fad8d96916d727fd00b

Quelldatensatz

uspto-grants-2015_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09067931B2