StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Tilmicosin → Decanoic Acid

HRID 2179870
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2179870
[CH3:1][CH2:2][C@H:3]1[O:20][C:18](=[O:19])[CH2:17][C@@H:16]([OH:21])[C@H:15]([CH3:22])[C@@H:14]([O:23][C@@H:24]2[O:29][C@H:28]([CH3:30])[C@@H:27]([OH:31])[C@H:26]([N:32]([CH3:34])[CH3:33])[C@H:25]2[OH:35])[C@@H:13]([CH2:36][CH2:37][N:38]2[CH2:43][C@@H:42]([CH3:44])[CH2:41][C@@H:40]([CH3:45])[CH2:39]2)[CH2:12][C@@H:11]([CH3:46])[C:9](=[O:10])[CH:8]=[CH:7][C:6]([CH3:47])=[CH:5][C@@H:4]1[CH2:48][O:49][C@@H:50]1[O:55][C@H:54]([CH3:56])[C@@H:53]([OH:57])[C@@H:52]([O:58][CH3:59])[C@H:51]1[O:60][CH3:61].OP([O-])(O)=O.OP([O-])([O-])=O.[Na+].[Na+].[Na+].[Cl-].[Cl-].[K+].[K+]>CN1CCCC1=O>[C:18]([OH:20])(=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:9][CH3:8].[C:18]([OH:20])(=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:9][CH2:8][CH2:7][CH3:6].[CH3:1][CH2:2][C@H:3]1[O:20][C:18](=[O:19])[CH2:17][C@@H:16]([OH:21])[C@H:15]([CH3:22])[C@@H:14]([O:23][C@@H:24]2[O:29][C@H:28]([CH3:30])[C@@H:27]([OH:31])[C@H:26]([N:32]([CH3:34])[CH3:33])[C@H:25]2[OH:35])[C@@H:13]([CH2:36][CH2:37][N:38]2[CH2:39][C@@H:40]([CH3:45])[CH2:41][C@@H:42]([CH3:44])[CH2:43]2)[CH2:12][C@@H:11]([CH3:46])[C:9](=[O:10])[CH:8]=[CH:7][C:6]([CH3:47])=[CH:5][C@@H:4]1[CH2:48][O:49][C@@H:50]1[O:55][C@H:54]([CH3:56])[C@@H:53]([OH:57])[C@@H:52]([O:58][CH3:59])[C@H:51]1[O:60][CH3:61]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 2

HCID 5282521TilmicosinHCID 24978514Phosphate Buffered Saline

Produkt 3

HCID 2969Decanoic AcidHCID 3893Lauric AcidHCID 5282521Tilmicosin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387
N-methyl-2-pyrrolidone
Lösungsmittel

Versuchsvorschrift

10 grams (0.0115 moles) of tilmicosin and 0.0253 moles of various carboxylic acids (such as, for example, decanoic, lauric, linoleic, or myristic acids, in individual assays) were taken in a flask and made up to a final volume of 100 ml with N-methyl-pyrrolidone and stirred for 60 minutes to obtain a clear solution. One ml aliquots of these solutions were sealed in dialysis bags, and the bags were suspended in flasks containing 150 ml of phosphate-buffered saline, pH 7.4. The salt was observed to precipitate in the bag within about 1 hour. Aliquots of saline were removed at various intervals and tilmicosin was determined by HPLC. The results with decanoic acid (C-10) and lauric acid (C-12) salts in FIG. 3 show that tilmicosin continued to diffuse out of the bag for more than 120 hours. Longer chain length acids caused a slower release of tilmicosin. Micotil® (Eli Lilly, Indianapolis, Ind.), a phosphate salt of tilmicosin, is readily soluble and rapidly diffuses from the bag.

Aufarbeitung

  1. customto obtain a clear solution
  2. customOne ml aliquots of these solutions were sealed in dialysis bags
  3. customthe bags were suspended in flasks
  4. customto precipitate in the bag within about 1 hour
  5. customAliquots of saline were removed at various intervals and tilmicosin

Quellen und Nachweise

ORD-Eintrag
ord-c3aa9180f2134a2c87d4796fe89c9112
Quelldatensatz
uspto-grants-2005_05
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US06887487B2

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion