Dichloromethane → 3-(3-Phenylsulfamoylphenyl)acryloyl chloride

HRID 2180379Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2180379
[C:1]1([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19]([OH:21])=O)[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:22]CCl>CN(C)C=O>[C:1]1([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19]([Cl:22])=[O:21])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 670195203-(3-Phenylsulfamoylphenyl)acrylic acid

Produkt 1

HCID 739894323-(3-Phenylsulfamoylphenyl)acryloyl chlorideAusbeute 100,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideKatalysator

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a suspension of 3-(3-phenylsulfamoylphenyl)acrylic acid (5a) (0.173 g, 0.57 mmol) in dichloromethane (2.3 ml) oxalyl chloride (0.17 ml, 1.95 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.185 g).

Aufarbeitung

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-32330055ba8947febc0cfaacb2a75418
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06888027B2

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