Dichloromethane → 3-(3-p-Tolylsulfamoyl-phenyl)-acryloyl chloride

HRID 2180384Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2180384
[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19](O)=[O:20])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1.[Cl:23]CCl>CN(C)C=O>[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19]([Cl:23])=[O:20])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 670195353-(3-p-Tolylsulfamoyl-phenyl)-acrylic acid

Produkt 1

HCID 739893963-(3-p-Tolylsulfamoyl-phenyl)-acryloyl chlorideAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideKatalysator

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a suspension of 3-(3-p-tolylsulfamoyl-phenyl)-acrylic acid (5d) (0.75 g, 2.36 mmol) in dichloromethane (10.0 ml) oxalyl chloride (0.62 ml, 7.08 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.79 g).

Aufarbeitung

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-82e91bf5cc314bae985e09aa4bb03eb9
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06888027B2

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