Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoate → HCID 86759709, Verbindung
Reaktionsgleichung
C(OP([CH2:9]/[C:10](/[CH3:17])=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13])(OCC)=O)C.[F:18]/[C:19](=[C:22](/[C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][C:33]=1[O:34][CH2:35][CH2:36][CH3:37])[O:30][C:29]([CH3:39])([CH3:38])[CH:28]=[C:27]2[CH:40]([CH3:42])[CH3:41])\[CH3:23])/[CH:20]=O>>[F:18]/[C:19](=[C:22](/[C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][C:33]=1[O:34][CH2:35][CH2:36][CH3:37])[O:30][C:29]([CH3:39])([CH3:38])[CH:28]=[C:27]2[CH:40]([CH3:41])[CH3:42])\[CH3:23])/[CH:20]=[CH:9]/[C:10](/[CH3:17])=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13]Komponenten
3
Versuchsvorschrift
Following General Procedure O, ethyl 4-(diethoxyphosphoryl)-3-methyl-but-2E-enoate (159 mg, 0.60 mmol) and (2E)-2-fluoro-3-(4-isopropyl-2,2-dimethyl-7-propoxy-2H-chromen-6-yl)but-2-enal (Compound 99, 72 mg, 0.21 mmol) were reacted to give the title compound as a yellow oil after purification by flash chromatography (silica gel, 5% ethyl acetate in hexane).
Aufarbeitung
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