4-(Chloromethyl)-5-methyl-2-(2-methylphenyl)-1,3-oxazole → HCID 10410562, Verbindung
Reaktionsgleichung
C[O:2][C:3](=[O:19])[CH:4]([O:15][CH2:16][CH2:17][CH3:18])[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[CH:9]2.Cl[CH2:21][C:22]1[N:23]=[C:24]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[CH3:34])[O:25][C:26]=1[CH3:27]>>[CH3:27][C:26]1[O:25][C:24]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[CH3:34])=[N:23][C:22]=1[CH2:21][N:11]1[C:12]2[C:8](=[CH:7][C:6]([CH2:5][CH:4]([O:15][CH2:16][CH2:17][CH3:18])[C:3]([OH:2])=[O:19])=[CH:14][CH:13]=2)[CH:9]=[CH:10]1Komponenten
3
Versuchsvorschrift
In analogy to the procedure described in example 44, rac-3-(1H-indol-5-yl)-2-propoxy-propionic acid methyl ester (preparation 6) was reacted with 4-chloromethyl-5-methyl-2-o-tolyl-oxazole to give rac-3-[1-(5-methyl-2-o-tolyl-oxazol-4-ylmethyl)-1H-indol-5-yl]-2-propoxy-propionic acid as light brown oil.
Quellen und Nachweise
- ORD-Eintrag
- ord-f45aa024856440e4a654907e1a068b1a
- Quelldatensatz
- uspto-grants-2005_05