2-(4-Trifluoromethylphenyl)-4-chloromethyl-5-methyloxazole → 2-Propoxypropanoic acid

Reaktionsgleichung

C[O:2][C:3](=[O:19])[CH:4]([O:15][CH2:16][CH2:17][CH3:18])[CH2:5]C1C=C2C(=CC=1)NC=C2.ClCC1N=C(C2C=CC(C(F)(F)F)=CC=2)OC=1C>>[CH2:16]([O:15][CH:4]([CH3:5])[C:3]([OH:19])=[O:2])[CH2:17][CH3:18]

Komponenten

Edukt 2

HCID 102363332-(4-Trifluoromethylphenyl)-4-chloromethyl-5-methyloxazole

HCID 69562937Methyl α-propoxy-1H-indole-5-propanoate

Produkt 1

HCID 144955462-Propoxypropanoic acid

Versuchsvorschrift

In analogy to the procedure described in example 44, rac-3-(1H-indol-5-yl)-2-propoxy-propionic acid methyl ester (preparation 6) was reacted with 4-chloromethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole to give rac-3-1-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl methyl]-1H-indol-5-yl}-2-propoxy-propionic acid as light yellow solid.

Quellen und Nachweise

ORD-Eintrag: ord-69050f0f31ab4c25a386ef72b9b664a6
Quelldatensatz: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06890947B2

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