Sodium Hydroxide → 2-(4-Bromophenyl)-2-methylpropanoic acid

HRID 218222Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 218222
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:15])([CH3:14])[C:9]([O:11]CC)=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+]>O1CCCC1.CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:15])([CH3:14])[C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 11277257Ethyl 2-(4-bromophenyl)-2-methylpropanoate

Produkt 1

HCID 109336792-(4-Bromophenyl)-2-methylpropanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of the product of Example 22A (3.7 g, 13.6 mmoles) in tetrahydrofuran (110.0 ml) and methanol (37.0 ml) was added 2 N sodium hydroxide (19.0 ml) and the solution was stirred at ambient temperature for about 16 hours. The reaction mixture was concentrated in vacuum down to the water layer, was cooled with an ice bath, and was acidified by addition of 2N hydrochloric acid. The precipitate was filtered off and was dried in vacuum to provide the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuum down to the water layer
  2. temperaturewas cooled with an ice bath
  3. additionwas acidified by addition of 2N hydrochloric acid
  4. filtrationThe precipitate was filtered off
  5. customwas dried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e4fab534b8164ed0aefc0af450add9b5
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198331B2

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