1H-Indazol-3-ylmethanol → HCID 178520025, Verbindung

HRID 2182334

Reaktionsgleichung

Reaktionsgleichung von HRID 2182334
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][OH:11])=[N:2]1>COCCOC.[O-2].[O-2].[Mn+4]>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[N:2]1

Komponenten

4

Edukt 1

HCID 1785200261H-Indazol-3-ylmethanol

Produkt 1

HCID 178520025HCID 178520025, VerbindungAusbeute 90,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 80711,2-DimethoxyethaneLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

A solution of 2.27 g of (1H-indazol-3-yl)methanol in 220 ml of 1,2-dimethoxyethane is added to 13.32 g of manganese dioxide. After one hour at a temperature in the region of 20° C., the reaction mixture is refluxed for 15 minutes. After cooling to a temperature in the region of 20° C., the reaction medium is filtered through a sinter funnel packed with Celite. The collected filtrate is concentrated under reduced pressure at a temperature in the region of 40° C. 2.02 g of 1H-indazole-3-carboxaldehyde are thus obtained in the form of a yellow powder, the characteristics of which are as follows:

Aufarbeitung

  1. temperaturethe reaction mixture is refluxed for 15 minutes
  2. filtrationthe reaction medium is filtered through a sinter funnel
  3. concentrationThe collected filtrate is concentrated under reduced pressure at a temperature in the region of 40° C

Quellen und Nachweise

ORD-Eintrag
ord-54dc7cf0cf6449acb0a74ba34f8f0f7e
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06897208B2

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