Trifluoroacetic acid → HCID 59909816, Verbindung

HRID 2183019Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2183019
[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])[O:10][N:9]=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([OH:17])=[O:16])[O:10][N:9]=2)=[CH:31][CH:32]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59909802HCID 59909802, Verbindung

Produkt 1

HCID 59909816HCID 59909816, VerbindungAusbeute 101 %

Versuchsvorschrift

tert-Butyl (3R)-3-{3-[(4-chlorophenoxy)methyl]-1,2,4-oxadiazol-5-yl}-6-cyclohexylhexanoate (Preparation 56) (215 mg, 0.46 mmol) was treated with trifluoroacetic acid (5 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 4 hours. The solvent was removed under reduced pressure and the residue azeotroped from toluene to afford the title compound (189 mg).

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe residue azeotroped from toluene

Quellen und Nachweise

ORD-Eintrag
ord-c3828588f2c946b9b5db644042361ec6
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06897306B2

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