Hydrochloric Acid → Moxifloxacin Hydrochloride

HRID 218344Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 218344
[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20].[ClH:30]>CO>[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20].[ClH:30]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 152946Moxifloxacin

Produkt 1

HCID 101526Moxifloxacin HydrochlorideAusbeute 105 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
2.5 °C

Versuchsvorschrift

Moxifloxacin base 50.0 g was stirred in 200.0 ml methanol for 10-15 minutes at 25-3-° C. The pH was adjusted to 1.0-2.0 using methanolic hydrochloric acid. The reaction mass was chilled to 0-5° C. and maintained for 1 hour. The solids were filtered and dried under vacuum at 85-90° C. to yield 52.5 g (105%) of moxifloxacin hydrochloride.

Aufarbeitung

  1. temperaturemaintained for 1 hour
  2. filtrationThe solids were filtered
  3. customdried under vacuum at 85-90° C.

Quellen und Nachweise

ORD-Eintrag
ord-a3cdaec056af441abb5560ca037053ad
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198451B2

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