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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 2183459Erstellt: 24. Oktober 2026

Hydrochloric Acid → (S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamine

https://huagongshe.com/de/reaction/2183459

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktHydrochloric AcidHCID 313—
Edukt(S)-{1-[3-(6-Methyl-pyridin-3-yloxy)-phenyl]-ethyl}-carbamic acid tert-butyl esterHCID 60004122—
LösungsmittelMethanolHCID 887—
LösungsmittelDiethyl EtherHCID 3283—
Produkt(S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamineHCID 60004124141,6%

Reaktionsschritte

(S)-{1-[3-(6-Methyl-pyridin-3-yloxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester (3.45 g, 10.52 mmol), hydrogen chloride in ether (36.8 mL, 1.0M) and methanol (5 mL) was stirred at room temperature for 6 h. The reaction mixture was concentrated in vacuo to provide the title compound (3.4 g, quantitative yield) as yellow solid.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06900210B2
Quelldatensatzuspto-grants-2005_05
ORD IDord-e63ac5ecff554945914a4d7b418d4464
Quellennotizuspto-grants-2005_05