HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → (S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | (S)-{1-[3-(6-Methyl-pyridin-3-yloxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester | HCID 60004122 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Produkt | (S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamine | HCID 60004124 | 141,6% |
Reaktionsschritte
(S)-{1-[3-(6-Methyl-pyridin-3-yloxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester (3.45 g, 10.52 mmol), hydrogen chloride in ether (36.8 mL, 1.0M) and methanol (5 mL) was stirred at room temperature for 6 h. The reaction mixture was concentrated in vacuo to provide the title compound (3.4 g, quantitative yield) as yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06900210B2 |
| Quelldatensatz | uspto-grants-2005_05 |
| ORD ID | ord-e63ac5ecff554945914a4d7b418d4464 |
| Quellennotiz | uspto-grants-2005_05 |