Hydrochloric Acid → (S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamine

HRID 2183459

Reaktionsgleichung

Reaktionsgleichung von HRID 2183459
C(OC(=O)[NH:7][C@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][C:17]2[CH:18]=[N:19][C:20]([CH3:23])=[CH:21][CH:22]=2)[CH:11]=1)[CH3:9])(C)(C)C.Cl>CCOCC.CO>[CH3:23][C:20]1[N:19]=[CH:18][C:17]([O:16][C:12]2[CH:11]=[C:10]([C@@H:8]([NH2:7])[CH3:9])[CH:15]=[CH:14][CH:13]=2)=[CH:22][CH:21]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 60004122(S)-{1-[3-(6-Methyl-pyridin-3-yloxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester

Produkt 1

HCID 60004124(S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamineAusbeute 141,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

(S)-{1-[3-(6-Methyl-pyridin-3-yloxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester (3.45 g, 10.52 mmol), hydrogen chloride in ether (36.8 mL, 1.0M) and methanol (5 mL) was stirred at room temperature for 6 h. The reaction mixture was concentrated in vacuo to provide the title compound (3.4 g, quantitative yield) as yellow solid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e63ac5ecff554945914a4d7b418d4464
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06900210B2

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