Triethylamine → 3-(2,5-Difluoro-phenyl)-N-{1-[3-(pyridin-4-ylamino)-phenyl]ethyl}-acrylamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Triethylamine	HCID 8471	—
Edukt	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Edukt	(S)-[3-(1-amino-ethyl)-phenyl]-pyridin-4-yl-amine	HCID 60004117	—
Edukt	2.5-Difluoro-chlorocinnamic acid	HCID 86759747	—
Katalysator	4-(Dimethylamino)pyridine	HCID 14284	—
Lösungsmittel	Dichloromethane	HCID 6344	—
Produkt	3-(2,5-Difluoro-phenyl)-N-{1-[3-(pyridin-4-ylamino)-phenyl]ethyl}-acrylamide	HCID 69800304	81,7%

Reaktionsschritte

A mixture of (S)-[3-(1-amino-ethyl)-phenyl]-pyridin-4-yl-amine (0.1 mmol), 2.5-difluoro-chlorocinnamic acid (0.1 mmol), EDAC.HCl (0.2 mmol), DMAP (0.1 mmol), triethylamine (0.3 mmol) in dichloromethane (2 mL) was stirred at room temperature overnight. The reaction mixture was purified by flash chromatography with 5% methnol in ethyl acetate to provide the title compound (31 mg) as a solid.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06900210B2
Quelldatensatz	uspto-grants-2005_05
ORD ID	ord-516a3a37db3a4d388f037877ad273a50
Quellennotiz	uspto-grants-2005_05