Trifluoroacetic acid → HCID 59075091, Verbindung

HRID 2184337Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2184337
[OH:1][CH2:2][C@@H:3]1[NH:7][C:6](=[O:8])[C:5]([CH3:10])([CH3:9])[CH2:4]1.[CH:11]([O:13][CH2:14][CH3:15])=[CH2:12].FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[CH2:11]([O:13][CH:14]([O:1][CH2:2][C@@H:3]1[NH:7][C:6](=[O:8])[C:5]([CH3:10])([CH3:9])[CH2:4]1)[CH3:15])[CH3:12]

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 8023Ethyl vinyl etherHCID 59075103HCID 59075103, Verbindung

Produkt 1

HCID 59075091HCID 59075091, VerbindungAusbeute 43,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of (R)-5-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one (4.0 g, 28 mmol), prepared as described in Tetrahedron 1998, 54 10295-10307, and ethyl vinyl ether (4 mL, 42 mmol) in chloroform (26 mL), was added a catalytic amount of trifluoroacetic acid (0.056 mL), and the reaction mixture was stirred for four hours at room temperature. The solution was then washed with a saturated solution of sodium bicarbonate and brine, and dried over magnesium sulfate. The crude oil obtained after evaporating the solvent, was purified by chromatography on silica gel using hexane:ethyl acetate 1:1 as a solvent, giving 2.6 g of (R)-5-(1-ethoxy-ethoxymethyl)-3,3-dimethyl-pyrrolidin-2-one.

Aufarbeitung

  1. washThe solution was then washed with a saturated solution of sodium bicarbonate and brine
  2. dry with materialdried over magnesium sulfate
  3. customThe crude oil obtained
  4. customafter evaporating the solvent
  5. customwas purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-9915ae513afa47158494a076450f7fa0
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06900336B2

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