Nitric Acid → 4-Mesyl-2-nitrotoluene

HRID 21844

Reaktionsgleichung

Reaktionsgleichung von HRID 21844
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)(=[O:3])=[O:4]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 18521p-Tolyl methyl sulfone

Produkt 1

HCID 6871254-Mesyl-2-nitrotoluene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel2×

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

68 g of 4-methylsulfonyltoluene in 400 ml of concentrated sulfuric acid were admixed at 0°-10° C. with a mixture of 80 ml of concentrated sulfuric acid and 31 ml of 65% strength by weight nitric acid. The reaction mixture was stirred at 10° C. for 2 hours and at room temperature for a further 2 hours. It was then poured onto about 1 kg of ice, and the solids were filtered off with suction, washed with water and dried at 50° C. under reduced pressure, to leave 85 g of 4-methylsulfonyl-2-nitrotoluene (melting point 112°-115° C.).

Aufarbeitung

  1. filtrationthe solids were filtered off with suction
  2. washwashed with water
  3. customdried at 50° C. under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6b452798bf2a4573bf046125764f2e48
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05424481

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