3-Chloro-4-iodoaniline → 3-Allyl-1-(4-amino-2-chlorophenyl)piperidin-2-one

HRID 218535

Reaktionsgleichung

Reaktionsgleichung von HRID 218535
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1I)[NH2:5].[CH2:10]([CH:13]1[CH2:18][CH2:17][CH2:16][NH:15][C:14]1=[O:19])[CH:11]=[CH2:12]>>[CH2:10]([CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([C:8]2[CH:7]=[CH:6][C:4]([NH2:5])=[CH:3][C:2]=2[Cl:1])[C:14]1=[O:19])[CH:11]=[CH2:12]

Komponenten

3

Edukt 2

HCID 2829263-Chloro-4-iodoanilineHCID 133803743-Allyl-2-piperidinone

Produkt 1

HCID 595867433-Allyl-1-(4-amino-2-chlorophenyl)piperidin-2-one

Versuchsvorschrift

Analogously to the process described under example 93A, 6.00 g (23.7 mmol) of 3-chloro-4-iodoaniline and 4.11 g (29.6 mmol) of the compound from example 96A are used to obtain 1.57 g (25% of theory) of the title compound. The purification is effected by suction filtration using silica gel with 2:1→1:2 cyclohexane/ethyl acetate as the eluent.

Quellen und Nachweise

ORD-Eintrag
ord-1072e6521e71422e8b7d16ab4d45c732
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198267B2

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