Trifluoroacetic acid → 4-(3,5-Dichlorophenoxy)piperidine

HRID 2185480Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2185480
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([O:21][C:22]2[CH:27]=[C:26]([Cl:28])[CH:25]=[C:24]([Cl:29])[CH:23]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[Cl:29][C:24]1[CH:23]=[C:22]([CH:27]=[C:26]([Cl:28])[CH:25]=1)[O:21][CH:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 22458487n-Tert-butoxycarbonyl-4-(3,5-dichlorophenoxy)piperidine

Produkt 1

HCID 224584124-(3,5-Dichlorophenoxy)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (10 mL) was added to a solution of N-tert-butoxycarbonyl-4-(3,5-dichlorophenoxy)piperidine (A, 815 mg) in dichloromethane (20 mL) at room temperature. After stirring at room temperature for 30 min, the reaction mixture was evaporated in vacuo. The residue was partitioned between chloroform and saturated sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate and then concentrated in vacuo to give the title compound, which was washed with hexane and used in the next reaction without further purification.

Aufarbeitung

  1. customthe reaction mixture was evaporated in vacuo
  2. customThe residue was partitioned between chloroform and saturated sodium hydrogen carbonate
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0e938db6a8f0498b9f01c9ccc8bba9cc
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06399629B1

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