(2S)-2-(((Phenylmethoxy)carbonyl)amino)butanoic acid → 1-(n-Benzyloxycarbonyl-2(s)-aminobutyryl)-2(s)-indolinecarboxylic acid n-butylamide

HRID 2185667Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2185667
[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([CH2:16][CH3:17])[C:13]([OH:15])=O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([NH:22][C:23]([C@@H:25]1[CH2:33][C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[NH:26]1)=[O:24])[CH2:19][CH2:20][CH3:21]>>[CH2:18]([NH:22][C:23]([C@@H:25]1[CH2:33][C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:26]1[C:13](=[O:15])[C@@H:12]([NH:11][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10])[CH2:16][CH3:17])=[O:24])[CH2:19][CH2:20][CH3:21]

Komponenten

3

Edukt 2

HCID 7349998(2S)-2-(((Phenylmethoxy)carbonyl)amino)butanoic acidHCID 114133182(s)-Indolinecarboxylic acid n-butylamide

Produkt 1

HCID 115249331-(n-Benzyloxycarbonyl-2(s)-aminobutyryl)-2(s)-indolinecarboxylic acid n-butylamide

Versuchsvorschrift

The process is performed as in Example 15 c), using 0.646 g (2.73 mmol) of N-benzyloxycarbonyl-2(S)-aminobutyric acid prepared as in Example 3 a) and 0.595 g (2.73 mmol) of the amide prepared in step b). An oil is obtained which is recrystallized from CCl4.

Aufarbeitung

  1. customAn oil is obtained which
  2. customis recrystallized from CCl4

Quellen und Nachweise

ORD-Eintrag
ord-542825ccd3e84971a76bb75cebfd81be
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06403561B1

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