1,2,3,4-Tetrahydro-1-naphthoic acid → HCID 68418747, Verbindung

HRID 218571

Reaktionsgleichung

Reaktionsgleichung von HRID 218571
[CH:1]1([C:11]([OH:13])=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[CH:14]([C:17]1[CH:22]=[CH:21][C:20]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][O:30][CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][O:32]2)=[CH:19][CH:18]=1)([CH3:16])[CH3:15]>>[CH:14]([C:17]1[CH:18]=[CH:19][C:20]([N:23]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][O:30][CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][O:32]2)[C:11]([CH:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3][CH2:2]2)=[O:13])=[CH:21][CH:22]=1)([CH3:16])[CH3:15]

Komponenten

3

Edukt 2

HCID 125981461,2,3,4-Tetrahydro-1-naphthoic acidHCID 67183577(4-Isopropylphenyl)[6-(tetrahydropyran-2-yloxy)hexyl]amine

Produkt 1

HCID 68418747HCID 68418747, VerbindungAusbeute 33,5 %

Versuchsvorschrift

By the reaction and treatment in the same manner as in Example 1 using 1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (1.1 g) and (4-isopropylphenyl)[6-(tetrahydropyran-2-yloxy)hexyl]amine (2.0 g) as starting materials, N-(4-isopropylphenyl)-N-[6-(tetrahydropyran-2-yloxy)hexyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.0 g) was obtained. By the reaction and treatment of this compound in the same manner as in Example 9, N-(6-hydroxyhexyl)-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.64 g) was obtained.

Quellen und Nachweise

ORD-Eintrag
ord-74a04fd4c42c46718a71016c75e78d51
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198454B2

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