Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1Komponenten
3
Versuchsvorschrift
A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p.>270° C. (ethanol).
Aufarbeitung
- temperatureat reflux for 30 hours
- filtrationwas filtered by suction
- washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound
Quellen und Nachweise
- ORD-Eintrag
- ord-b5b8d4754fe64f44b7a713d3becbb443
- Quelldatensatz
- uspto-grants-2002_06
- Patentnummer
- US06403594B1
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