Hydrochloric Acid → 5-Ethyl-2-pyridyl-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetic acid

HRID 2187051Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2187051
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]([CH2:19][C:20]([O:22]CC)=[O:21])[C:11](=[O:18])[C:12]([CH:15]([CH3:17])[CH3:16])([CH3:14])[N:13]=2)=[N:7][CH:8]=1)[CH3:2].[OH-].[Na+].Cl>O1CCCC1>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]([CH2:19][C:20]([OH:22])=[O:21])[C:11](=[O:18])[C:12]([CH:15]([CH3:17])[CH3:16])([CH3:14])[N:13]=2)=[N:7][CH:8]=1)[CH3:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22450190Ethyl 2-(5-ethyl-2-pyridyl)-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetate

Produkt 1

HCID 224501785-Ethyl-2-pyridyl-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A stirred solution of ethyl 2-(5-ethyl-2-pyridyl) -4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetate (2.12 g, 6.41 mmol) in tetrahydrofuran is treated with 2N sodium hydroxide (8 mL). The resulting mixture is stirred at room temperature for 16 hours. After this period, the reaction mixture is concentrated in vacuo to obtain a residue. The residue is acidified with concentrated hydrochloric acid and then extracted with ether. The organic extract is dried over magnesium sulfate, vacuum filtered through diatomaceous earth and concentrated in vacuo to give the title product as a white solid, mp 134-136° C.

Aufarbeitung

  1. waitAfter this period
  2. concentrationthe reaction mixture is concentrated in vacuo
  3. customto obtain a residue
  4. extractionextracted with ether
  5. extractionThe organic extract
  6. dry with materialis dried over magnesium sulfate, vacuum
  7. filtrationfiltered through diatomaceous earth
  8. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fa78705fcc544fc5a3affb21f807b690
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06407217B1

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