Dichloromethane → Ramipril

HRID 2187112

Reaktionsgleichung

Reaktionsgleichung von HRID 2187112
C(O)(=O)/C=C\C(O)=O.C([O:16][C:17]([C@H:19]1[N:23]([C:24](=[O:42])[C@@H:25]([NH:27][C@H:28]([C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH3:26])[C@H:22]2[CH2:43][CH2:44][CH2:45][C@H:21]2[CH2:20]1)=[O:18])C1C=CC=CC=1.ClCCl>C(N(CC)CC)C>[CH3:41][CH2:40][O:39][C:37]([C@@H:28]([NH:27][C@H:25]([C:24]([N:23]1[C@H:19]([C:17]([OH:18])=[O:16])[CH2:20][C@H:21]2[C@@H:22]1[CH2:43][CH2:44][CH2:45]2)=[O:42])[CH3:26])[CH2:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)=[O:38]

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 10121882HCID 10121882, Verbindung

Produkt 1

HCID 5362129Ramipril

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Reaktionsbedingungen

Temperatur
2.5 °C

Versuchsvorschrift

A 1.0 g portion of (2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid benzyl ester maleic acid salt 1 was placed into 100 mL of dichloromethane, and was cooled to 0-5° C. Triethylamine (0.19 g) was added to the mixture. The resulting mixture was washed with water, and the organic phase was evaporated to give an oil. This oil was deprotected using hydrogenolysis, as per examples stated in EP 079022 to give Ramipril as a white solid.

Aufarbeitung

  1. washThe resulting mixture was washed with water
  2. customthe organic phase was evaporated
  3. customto give an oil

Quellen und Nachweise

ORD-Eintrag
ord-2ba52ce1ab474547a63de27377c6daf5
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06407262B1

Verknüpfte Notizen

Wird geladen…