HCID 15376563, Verbindung → HCID 11034420, Verbindung

HRID 2187502Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2187502
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]([CH2:19][CH2:20][NH:21][C:22]([O:24][CH3:25])=[O:23])[CH:16]=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[NH2:5][S:6]([C:9]1[CH:18]=[C:17]([CH2:19][CH2:20][NH:21][C:22]([O:24][CH3:25])=[O:23])[CH:16]=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])(=[O:7])=[O:8]

Komponenten

3

Edukt 1

HCID 15376563HCID 15376563, Verbindung

Produkt 1

HCID 11034420HCID 11034420, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of 1.4 g (3.8 mmol) of methyl 2-tert-butylaminosulfonyl-4-[2-(methoxycarbonylamino]ethyl]benzoate in 20 ml of trifluoroacetic acid was stirred for 8 hours at room temperature. The batch was evaporated completely, re-evaporated with toluene, and the residue obtained was crystallized with ethyl acetate/diisopropyl ether. This gave 0.54 g (45%) of methyl 2-aminosulfonyl-4-[2-(methoxycarbonylamino)-ethyl]benzoate of m.p.: 146-149° C.

Aufarbeitung

  1. customThe batch was evaporated completely
  2. customre-evaporated with toluene
  3. customthe residue obtained
  4. customwas crystallized with ethyl acetate/diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-1717c96496a64fa78f4d80e681b9ae0e
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06410483B1

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