Triethylamine → N-[2-(3-cyanophenoxy)ethyl]-4-(3,4-dimethoxybenzoyl)benzamide

HRID 2187960Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2187960
Cl.[NH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:30]=[CH:31][C:32]=1[O:33][CH3:34])[C:19]([C:21]1[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[CH:23][CH:22]=1)=[O:20].ON1C2C=CC=CC=2N=N1.C(N(CC)CC)C.Cl.CN(C)CCCN=C=NCC>CN(C)C=O>[C:9]([C:8]1[CH:7]=[C:6]([CH:13]=[CH:12][CH:11]=1)[O:5][CH2:4][CH2:3][NH:2][C:25](=[O:26])[C:24]1[CH:28]=[CH:29][C:21]([C:19](=[O:20])[C:18]2[CH:30]=[CH:31][C:32]([O:33][CH3:34])=[C:16]([O:15][CH3:14])[CH:17]=2)=[CH:22][CH:23]=1)#[N:10]

Komponenten

7

Edukt 5

HCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 226451983-(2-Aminoethoxy)benzonitrile hydrochlorideHCID 226452014-(3,4-Dimethoxybenzoyl)benzoic acid

Produkt 1

HCID 22645151N-[2-(3-cyanophenoxy)ethyl]-4-(3,4-dimethoxybenzoyl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

0.68 g (3.45 mmol) of 3-(2-aminoethoxy)benzonitrile monohydrochloride was dissolved in 20 ml of N,N-dimethylformamide (dehydrated). 0.9 g (3.14 mmol) of 4-(3,4-dimethoxybenzoyl)benzoic acid, 0.47 g (3.45 mmol) of 1-hydroxybenzotriazole, 0.48 ml (3.45 mmol) of triethylamine and 0.66 g (3.45 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride were added to the obtained solution, and they were stirred overnight. The solvent was evaporated, and the residue was treated with ethyl acetate as the extraction solvent in an ordinary manner to obtain the title compound.

Aufarbeitung

  1. customThe solvent was evaporated
  2. additionthe residue was treated with ethyl acetate as the extraction solvent in an ordinary manner

Quellen und Nachweise

ORD-Eintrag
ord-050476c3305948d3acb32b3dd289b06a
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06410538B2

Notizen zur Reaktion

Wird geladen…