Sodium Hydroxide → cis-3-Azidomethylcyclopentancarboxylic acid

HRID 2187993Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2187993
[N:1]([CH2:4][C@@H:5]1[CH2:9][CH2:8][C@H:7]([C:10]([O:12]C)=[O:11])[CH2:6]1)=[N+:2]=[N-:3].[OH-].[Na+]>>[N:1]([CH2:4][C@@H:5]1[CH2:9][CH2:8][C@H:7]([C:10]([OH:12])=[O:11])[CH2:6]1)=[N+:2]=[N-:3]

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 86758274Methyl cis-3-azidomethylcyclopentancarboxylate

Produkt 1

HCID 86758275cis-3-Azidomethylcyclopentancarboxylic acidAusbeute 91 %

Versuchsvorschrift

A mixture of methyl cis-3-azidomethylcyclopentancarboxylate (1.2 g, 6.5 mmol) and 1 N sodium hydroxide (12.0 mL, 12 mmol) was stirred at room temperature for about 8 h. The alkaline mixture was extracted with chloroform. The aqueous layer was acidified with hydrochloric acid and extracted twice with chloroform. Combined chloroform extracts from the acidic mixture were dried over sodium sulfate, filtered and concentrated to give about 1.0 g (91%) of cis-3-azidomethylcyclopentancarboxylic acid.

Aufarbeitung

  1. extractionThe alkaline mixture was extracted with chloroform
  2. extractionextracted twice with chloroform
  3. dry with materialCombined chloroform extracts from the acidic mixture were dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-3c6b04da23ea4e3a956934210c23a89d
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06410594B1

Notizen zur Reaktion

Wird geladen…