Methylamine → 3-[(2-chloro-4-iodophenyl)amino]-N-methylisonicotinamide

Reaktionsgleichung

[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH3:19][NH2:20]>>[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:20][CH3:19])=[O:14]

Komponenten

Edukt 2

HCID 6329Methylamine

HCID 576496513-[(2-Chloro-4-iodophenyl)amino]isonicotinic acid2×

Produkt 1

HCID 116681963-[(2-chloro-4-iodophenyl)amino]-N-methylisonicotinamide

Versuchsvorschrift

3-[(2-chloro-4-iodophenyl)amino]-N-methylisonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.32 mmol of 3-[(2-chloro-4-iodophenyl)amino]isonicotinic acid (intermediate 2) and 0.43 mmol of monomethylamine LC/MS [9.23 min; 389 (M+1)]

Quellen und Nachweise

ORD-Eintrag: ord-a83903aa13d34a3a99596f189eaafa30
Quelldatensatz: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08198457B2

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