Hydrochloric Acid → 2-Chloro-7-(pentan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

HRID 2189261Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2189261
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10][CH3:11])[C:5](/[CH:14]=[CH:15]\OCC)=[CH:4][N:3]=1.Cl>CCO>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[CH:14]=[CH:15][N:8]([CH:9]([CH2:10][CH3:11])[CH2:12][CH3:13])[C:6]=2[N:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 58015730[2-Chloro-5-((Z)-2-ethoxy-vinyl)-pyrimidin-4-yl]-(1-ethylpropyl)-amine

Produkt 1

HCID 580159322-Chloro-7-(pentan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of [2-Chloro-5-((Z)-2-ethoxy-vinyl)-pyrimidin-4-yl]-(1-ethylpropyl)-amine (1.1 g, 4.07 mmol) in EtOH (8 mL) is added concentrated HCl (0.1 mL) at ambient temperature. The reaction mixture is sealed in a microwave reactor and heated at 100° C. for 10 mins. After cooling down the mixture is concentrated in vacuo to provide 2-Chloro-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine. The crude product is used as it is. The material can be purified by flash chromatography (SiO2, EtOAc:Hexane=1:5).

Aufarbeitung

  1. customThe reaction mixture is sealed in a microwave reactor
  2. temperatureAfter cooling down the mixture
  3. concentrationis concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3cc26e9220f34baf8b4718d6eb056d7e
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324225B2

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