Ethyl 4-bromo-5-(3-chloro-4-fluorophenyl)furan-2-carboxylate → Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-carboxylate

HRID 2190118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2190118
[Cl:1][C:2]1[CH:3]=[C:4](C2C=C(C(OCC)=O)OC=2C2C=CC=C(C#N)C=2)[CH:5]=[C:6]([F:8])[CH:7]=1.Br[C:28]1[CH:29]=[C:30]([C:41]([O:43][CH2:44][CH3:45])=[O:42])[O:31][C:32]=1[C:33]1[CH:38]=[CH:37][C:36]([F:39])=[C:35]([Cl:40])[CH:34]=1>>[Cl:40][C:35]1[CH:34]=[C:33]([C:32]2[O:31][C:30]([C:41]([O:43][CH2:44][CH3:45])=[O:42])=[CH:29][C:28]=2[C:4]2[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([Cl:1])[CH:3]=2)[CH:38]=[CH:37][C:36]=1[F:39]

Komponenten

3

Edukt 2

HCID 58064794Ethyl 4-bromo-5-(3-chloro-4-fluorophenyl)furan-2-carboxylateHCID 58064795Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

Produkt 1

HCID 58064790Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-carboxylate

Versuchsvorschrift

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 11A starting with the compound from Example 6A. Purification is carried out using the mobile phase: cyclohexane/ethyl acetate (50:1). 1.07 g (63% of theory) of the title compound with a purity of 81% are obtained.

Aufarbeitung

  1. customPurification

Quellen und Nachweise

ORD-Eintrag
ord-0d7189686283479f9b9202a8373168ee
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324268B2

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