Ethyl 4-bromo-5-(4-fluorophenyl)furan-2-carboxylate → Ethyl 4-(3-chlorophenyl)-5-(4-fluorophenyl)furan-2-carboxylate

HRID 2190119Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2190119
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16](C#N)[CH:15]=2)[CH:5]=[C:6](F)[CH:7]=1.BrC1C=C(C(OCC)=O)OC=1C1C=CC([F:39])=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([F:39])=[CH:16][CH:15]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 58064766Ethyl 4-bromo-5-(4-fluorophenyl)furan-2-carboxylateHCID 58064795Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

Produkt 1

HCID 58064804Ethyl 4-(3-chlorophenyl)-5-(4-fluorophenyl)furan-2-carboxylate

Versuchsvorschrift

The synthesis of the title compound takes place in analogy to the synthesis of the compound from Example 11A starting with the compound from Example 7A. Extraction is carried out with dichloromethane and purification with the mobile phase cyclohexane/ethyl acetate (30:1). 4.12 g (41% of theory) of the title compound with a purity of 50% are obtained.

Aufarbeitung

  1. extractionExtraction
  2. customis carried out with dichloromethane and purification with the mobile phase cyclohexane/ethyl acetate (30:1)

Quellen und Nachweise

ORD-Eintrag
ord-a1905e68fcb840e5a4eebf8afbb13c80
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324268B2

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