Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylate → Ethyl 4,5-bis(3-chlorophenyl)furan-2-carboxylate

HRID 2190120Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2190120
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16](C#N)[CH:15]=2)[CH:5]=[C:6](F)[CH:7]=1.BrC1C=C(C(OCC)=O)OC=1C1C=CC=C([Cl:39])C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:39])[CH:15]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 58064772Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylateHCID 58064795Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

Produkt 1

HCID 58064774Ethyl 4,5-bis(3-chlorophenyl)furan-2-carboxylate

Versuchsvorschrift

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 11A starting with the compound from Example 5A. Extraction is carried out with dichloromethane and purification is by preparative HPLC (RP18 column; eluent: acetonitrile/water gradient). 452 mg (34% of theory) of the title compound are obtained.

Aufarbeitung

  1. extractionExtraction
  2. customis carried out with dichloromethane and purification

Quellen und Nachweise

ORD-Eintrag
ord-8fded2013afd4d1f818084ddb25f86df
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324268B2

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